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As far as I am involved it’s all the things carefully, eat your fruit and veg and exercise. Methylation been found on a range of lysine residues in varied histones: K4 (utilizing the one-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular area of histone H4 2 and K26 of histone H1B 3 Several proteins answerable for the methylation of specific residues have been characterized, and all however one of these contains a SET domain