Background: Monitoring of an animal’s blood glucose focus is critical for diagnostic and therapeutic selections. Over the previous few a long time, portable blood glucose meters (PBGMs) have been used to monitor blood glucose concentrations in animals. Recently, new and improved PBGMs have been made accessible available on the market. Objective: The aim of this examine was to evaluate 4 PBGMs to be used in canines and cats. Animals and strategies: A total of 155 venous blood samples of dogs and eighty five venous blood samples of cats have been examined using 4 PBGMs. Control options from manufacturers have been used to find out the precision of every meter. The coefficient of variation was calculated to find out precision throughout a set of replicates. Pearson’s correlation analysis, Passing-Bablok regression, and Bland-Altman analysis had been used to determine the accuracy of four PBGMs in opposition to the hexokinase reference method. Error grid analysis was used to evaluate clinical relevance. Results: All PBGMs, besides CERA-PET®, have been clinically acceptable for monitoring blood glucose concentrations