Quantitatively determining physiological parameters at a microscopic degree within the retina furthers the understanding of the molecular pathways of blinding diseases, similar to diabetic retinopathy and glaucoma. An important parameter, which has but to be quantified noninvasively, is the retinal oxygen metabolic fee (rMRO 2). Quantifying rMRO 2 is challenging because two parameters, the blood circulate rate and hemoglobin oxygen saturation (sO 2), have to be measured collectively. We mixed photoacoustic ophthalmoscopy (PAOM) with spectral domain-optical coherence tomography (SD-OCT) to deal with this challenge, in which PAOM measured the sO 2 and SD-OCT mapped the blood movement fee. This quantitative methodology might shed new mild on each basic research and clinical care in ophthalmology sooner or later. T he demand for treating blindness and low vision continue to escalate as human longevity will increase worldwide. By 2004 1 , for example, blindness and BloodVitals insights low imaginative and prescient had affected more than three million Americans aged forty years and older