nonnenmacher.deThese tails are subject to several submit-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and that are structurally not associated to SET-domain proteins 4 - 6 Latest work means that SET-area-containing proteins methylate a couple of proteins in addition to histones (see later)